File name: The Art And Science Of Physiologically-Based Pharmacokinetics Modeling Pdf

Rating: 4.6/5 (Based on 1498 votes)

13498 downloads

========================

👉The Art And Science Of Physiologically-Based Pharmacokinetics Modeling Pdf

========================

Physiologically based pharmacokinetic (PBPK) modeling is one approach that enables integration of physiological, chemical, and drug-dependent preclinical and clinical information to model an . Connecting basic and applied science, this book explores the potential of PBPK modeling for improving therapeutics and is designed for a wide audience encompassing graduate students . This state‑of‑the‑art text describes the science behind the system and drug‑dependent com‑ ponents of PBPK models, its applications in translational and regulatory science, e.g., guiding .  May 23, · Semantic Scholar extracted view of The Art and Science of Physiologically-Based Pharmacokinetics Modeling by Rodrigo Cristofoletti et al. Feb 7, · Physiologically based pharmacokinetic (PBPK) models of small molecules have become mainstream in drug development and in academic research. The use of PBPK models is continuously expanding with the majority of work now focusing on predictions of drug-drug interactions, drug-disease interactions, and changes in drug disposition across lifespan. 2 PHYSIOLOGICALLY-BASED MODELING 13 Introduction 13 Examples of Physiological Modeling 14 Need for Physiological Models in the Pharmaceutical Industry 15 Organs as Compartments 15 Bottom-Up vs. Top-Down Modeling in Pharmacokinetics 16 References 16 3 REVIEW OF PHARMACOKINETIC PRINCIPLES 17 Introduction